The Main Street makes its first appearance in "Headhunters." Dipper and Mabel Pines walk along it to the Skull Fracture bar, and watch Tats drive away a miner. Later, Dipper, Mabel, Sheriff Blubs, and Deputy Durland go to the Gravity Falls Gossiper building on Main Street to confront Toby Determined.
In "Irrational Treasure," many residents of the town gather there to celebrate Pioneer Day, engaging in activities like panning for gold, candle dipping, and listening to the opening ceremonies. Dipper and Mabel read about the Northwest Cover-up at the street's statue of Nathaniel Northwest.
In "Not What He Seems," Main Street is pictured during a gravity anomaly as various roofs and buildings float in the air.
Known features of Main Street include the following:
- Town square
- Police headquarters
- Statue of Nathaniel Northwest
- Hardware store
- Gravity Falls Gossiper
- Skull Fracture male biker bar
- Various Shops
- A Cafe
- Big Gunz Laser Tag